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Home - Products - Endocrinology/Hormones - 5-HT Receptor - GR 125743

GR 125743

CAS No. 148547-33-5

GR 125743( —— )

Catalog No. M22737 CAS No. 148547-33-5

GR 125743 is a novel antagonist of 5-HT1B/1D receptor.GR-125743, a new radiolabelled derivative of a compound that exhibits selective antagonistic properties with respect to the serotonin human (h5-HT1D) and human (h5-HT1B) receptors. The compound has been characterized for its ability to label the cloned h5-HT1D and h5-HT1B receptors.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    GR 125743
  • Note
    Research use only, not for human use.
  • Brief Description
    GR 125743 is a novel antagonist of 5-HT1B/1D receptor.GR-125743, a new radiolabelled derivative of a compound that exhibits selective antagonistic properties with respect to the serotonin human (h5-HT1D) and human (h5-HT1B) receptors. The compound has been characterized for its ability to label the cloned h5-HT1D and h5-HT1B receptors.
  • Description
    GR 125743 is a novel antagonist of 5-HT1B/1D receptor.GR-125743, a new radiolabelled derivative of a compound that exhibits selective antagonistic properties with respect to the serotonin human (h5-HT1D) and human (h5-HT1B) receptors. The compound has been characterized for its ability to label the cloned h5-HT1D and h5-HT1B receptors.
  • In Vitro
    GR 125743 has a Kd of 0.61 nM for h5-HT1B.
  • In Vivo
    GR 125743 (0.3 mg/kg; i.p.) produces significant decreases in extracellular 5-HT in the frontal cortex of the conscious guinea pig. Animal Model:Male Dunkin Hartley guinea-pigs (350-450 g)Dosage:0.3 mg/kg Administration:Intraperitoneal injection Result:Produced significant transient increases in extracellular 5-HT.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT1B/1D
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    148547-33-5
  • Formula Weight
    416.53
  • Molecular Formula
    C25H28N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (240.08 mM)
  • SMILES
    COc1ccc(NC(=O)c2ccc(c(C)c2)-c2ccncc2)cc1N1CCN(C)CC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. T Doménech, J Beleta, J M Palacios,et al.Characterization of human serotonin 1D and 1B receptors using [3H]-GR-125743, a novel radiolabelled serotonin 5HT1D/1B receptor antagonist.Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):328-34.
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